What makes a retinol formula stable?

Retinol keeps its potency longest in an anhydrous base with antioxidants.

Evidence

Source:: Temova Rakuša Ž et al. Pharmaceutics. 2021;13(10):1738
Applies to:: Formulations containing retinol
What this does not establish:: How a given product performs on your skin. Finished-product pH and concentration are rarely published, so this describes the chemistry, not a measurement of any specific product.
Last reviewed:: 2026-09-26

In practice

Retinol here sits alongside antioxidants that slow its oxidation, which is the formulation pattern associated with better retention of activity over a product's life. Opaque, air-restricting packaging matters just as much as the formula for this ingredient.

Dermasift analyses skincare formulations against published cosmetic science. This is information, not medical advice — for a diagnosed skin condition, speak to a dermatologist.

Check this against a product’s ingredient list

What makes a retinol formula stable?

Retinol keeps its potency longest in an anhydrous base with antioxidants.

Evidence

Source:: Temova Rakuša Ž et al. Pharmaceutics. 2021;13(10):1738
Applies to:: Formulations containing retinol
What this does not establish:: How a given product performs on your skin. Finished-product pH and concentration are rarely published, so this describes the chemistry, not a measurement of any specific product.
Last reviewed:: 2026-09-26

In practice

Dermasift analyses skincare formulations against published cosmetic science. This is information, not medical advice — for a diagnosed skin condition, speak to a dermatologist.

Check this against a product’s ingredient list