What does urea do in skincare?

Urea hydrates at low concentrations and becomes keratolytic near 10%.

Evidence

Source:: Celleno L. Dermatol Ther. 2018;31(6):e12690
Applies to:: Formulations containing urea
What this does not establish:: How a given product performs on your skin. Finished-product pH and concentration are rarely published, so this describes the chemistry, not a measurement of any specific product.
Last reviewed:: 2026-09-26

In practice

Urea works as a humectant at low concentrations and becomes keratolytic — actively loosening thickened skin — at roughly 10% and above. Its position here suggests the lower, hydrating range rather than the exfoliating one.

Dermasift analyses skincare formulations against published cosmetic science. This is information, not medical advice — for a diagnosed skin condition, speak to a dermatologist.

Check this against a product’s ingredient list

What does urea do in skincare?

Urea hydrates at low concentrations and becomes keratolytic near 10%.

Evidence

Source:: Celleno L. Dermatol Ther. 2018;31(6):e12690
Applies to:: Formulations containing urea
What this does not establish:: How a given product performs on your skin. Finished-product pH and concentration are rarely published, so this describes the chemistry, not a measurement of any specific product.
Last reviewed:: 2026-09-26

In practice

Dermasift analyses skincare formulations against published cosmetic science. This is information, not medical advice — for a diagnosed skin condition, speak to a dermatologist.

Check this against a product’s ingredient list